The Efficacy of Autologous Plasma Therapy in Patients with Chronic Urticaria

Background: Chronic urticaria is an allergic skin disease characterized by severe pruritic wheal persisting at least for 6 weeks. This study aimed to evaluate the efficacy of plasma therapy used for the first time for the treatment of idiopathic chronic urticaria. Materials and Methods: In this case series study, the quality of life (QOL) of 30 patients with idiopathic chronic urticaria (autoimmune and spontaneous) referred to allergy clinic was evaluated before and after autologous plasma therapy by using standard questionnaires (DLQI and TSS). Results: The findings showed that the means of DLQI and TSS scores in the patients after plasma therapy was significantly reduced. The findings showed that the means of TSS scores in the patients after plasma therapy was significantly reduced (p<0/001). Moreover, it was found that plasma therapy was significantly effective patients with idiopathic chronic urticaria (autoimmune and spontaneous) by using standard questionnaires (TSS)(p=0.001). The findings showed that the means of DLQI  scores in the patients after plasma therapy was significantly reduced (p=<0.001) means of DLQI  scores in the women in contrast to men after plasma therapy was significantly reduced ( p=0.04) .This indicates that the improvement of the QOL in the patients. Moreover, it was found that plasma therapy was significantly effective in both sexes. Conclusion: The results of the present study suggest that autologous plasma therapy could be a suitable method for the treatment of patients with idiopathic chronic urticaria.